Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
نویسندگان
چکیده
منابع مشابه
Natural Product Derivatives as Promising Anti-Pancreatic Cancer Agents
................................................................................................................................................ 5 INTRODUCTION ....................................................................................................................................... 6 NATURAL PRODUCTS IN MEDICINAL CHEMISTRY ..............................................................
متن کاملSystemic Targeted Alpha Radiotherapy for Cancer
Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...
متن کاملAnti Cancer Drugs Used for Targeted Therapy
A primary goal of targeted therapy is to fight cancer cells with more precision and potentially fewer side effects. For this reason it is a promising therapy for the 3rd millennium1. Traditional cytotoxic chemotherapy works primarily through the inhibition of cell division. In addition to cancer cells, other rapidly dividing cells (e.g. hair, gastrointestinal epithelium, bone marrow) are affect...
متن کاملBioassay Methods useful to select the natural product cancer chemopreventive agents
Prevention of malignant disease such as cancer is obviously much more important than therapy, so primary prevention tactics should be invoked with the greatest possible effort. Because delaying a disease such as cancer is somehow equivalent to cure and it is now generally accepted that cancer can be managed through chemopreventive interventions. Since a considerable number of known cancer chemo...
متن کاملTotal synthesis of (-)-minquartynoic acid: an anti-cancer, anti-HIV natural product.
[structure: see text] The tetraacetylenic compound, (S)-minquartynoic acid (1), is synthesized in seven linear steps and 17% overall yield from commercially available azelaic acid monomethyl ester. The key step is a one-pot three-component Cadiot-Chodkiewicz reaction to construct the tetrayne unit without using either a diyne or a triyne intermediate.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2019
ISSN: 1552-4450,1552-4469
DOI: 10.1038/s41589-019-0304-8